Endocrine Abstracts

Recurrent miscarriage (RM) is defined as ≥3 consecutive pregnancy losses and occurs in 1–3% of fertile couples. No specific early biomarkers with high predictive value of threatening miscarriage have been identified. Using GeneChips (Affymetrix), we profiled whole-genome differential gene expression in RM placental tissue compared to uncomplicated pregnancies matched for gestational age. In cases of RM, significantly increased placental mRNA expression of TNF-relate...